期刊
FEBS LETTERS
卷 584, 期 9, 页码 1642-1652出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.10.043
关键词
Glycosphingolipid; Fatty acid chain; Microdomain; Src family kinase
资金
- Mizutani Foundation for Glycoscience
- Hamaguchi Foundation for the Advancement of Biochemistry
- High-Tech Research Center
Lactosylceramide (LacCer), a neutral glycosphingolipid, is abundantly expressed on human neutrophils, and specifically recognizes several pathogenic microorganisms. LacCer forms membrane microdomains coupled with the Src family kinase Lyn on the plasma membrane, and ligand binding to LacCer activates Lyn, resulting in neutrophil functions. In contrast, neutrophilic differentiated HL-60 cells do not have Lyn-associated LacCer-enriched microdomains and lack LacCer-mediated functions. In neutrophil plasma membranes, the very long fatty acid C24:0 and C24: 1 chains are the main components of LacCer, whereas plasma membrane of D-HL-60 cells mainly includes C16-LacCer species. Here, we suggest that LacCer species containing very long fatty acid chains are indispensable for the association of Lyn with LacCer-enriched microdomains and LacCer-mediated functions. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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