期刊
FEBS LETTERS
卷 583, 期 8, 页码 1309-1313出版社
WILEY
DOI: 10.1016/j.febslet.2009.03.027
关键词
L-Arabinose; L-Xylulose reductase; D-Mannitol metabolism; Short chain dehydrogenase/reductase; Aspergillus niger
资金
- Austrian Science Foundation [P19421]
- Dutch Technology Foundation STW
- Ministry of Economic Affairs [07063]
- Austrian Science Fund (FWF) [P19421] Funding Source: Austrian Science Fund (FWF)
The Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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