期刊
FEBS LETTERS
卷 583, 期 22, 页码 3725-3730出版社
WILEY
DOI: 10.1016/j.febslet.2009.10.002
关键词
MicroRNA; p53; RNA interference; Tumor suppressor; Apoptosis; DNA damage
资金
- NIH [1P20RR025179]
MicroRNA (miRNA) are a class of non-coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA-125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA-125 (miRNA-125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR-125a and the 3'-UTR of p53. Our findings add miRNA-125a to the growing list of miRNA with oncogenic targets. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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