期刊
FEBS LETTERS
卷 583, 期 22, 页码 3605-3610出版社
WILEY
DOI: 10.1016/j.febslet.2009.10.034
关键词
Telomerase; Telomerase RNA; Telomere; Senescence; Subtelomere; Candida glabrata
资金
- GDR 2354 CNRS
- La Ligue contre le cancer
- ANR GENARISE [ANR-05-BLAN-0331]
- Human Frontier Science Program [RGP0032/2005-C]
- ministere de l'Enseignement superieur et de la Recherche
- Agence Nationale de la Recherche (ANR) [ANR-05-BLAN-0331] Funding Source: Agence Nationale de la Recherche (ANR)
Telomerase, the key enzyme essential for the maintenance of eukaryotic chromosome ends, contains a reverse transcriptase and an RNA that provides the template for the synthesis of telomeric repeats. Here, we characterize the telomerase subunits in the hemiascomycete yeast Candida glabrata. We propose a secondary structure model for the telomerase RNA that is the largest described to date. Telomerase deletion mutants show a progressive shortening of telomeres and a modest loss of viability. Frequent post-senescence survivors emerge that possess long telomeric repeat tracts. We suggest that the high telomere length heterogeneity accounts for this distinct senescence phenotype. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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