期刊
FEBS LETTERS
卷 584, 期 3, 页码 549-554出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.11.097
关键词
Plastid; Apicoplast; Malaria; Carbon; Energy; Plasmodium
资金
- National Health and Medical Research Council Program
- Australian Research Council Federation Fellowship
- Howard Hughes Medical Institute
- Transregional Collaborative Research Center TR1
- DFG [WE 2231/6-1]
- Australian Federal Government
- University of Melbourne
The malaria parasite harbours an indispensable plastid known as the 'apicoplast'. The apicoplast's exact role remains uncertain, but it houses components involved in fatty acid, isoprenoid and haem biosyntheses. These pathways offer opportunities to develop anti-malarials. In the absence of photosynthesis, how apicoplast anabolism is fuelled is unclear. Here we investigated plant-like transporters of the apicoplast and measured their substrate preferences using a novel cell-free assay system to explore the carbon and energy sources of the apicoplast. The transporters exchange triose phosphate and phosphoenolpyruvate for inorganic phosphate, demonstrating that the apicoplast taps into host-derived glucose to fuel its metabolism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据