期刊
FEBS LETTERS
卷 584, 期 2, 页码 252-264出版社
WILEY
DOI: 10.1016/j.febslet.2009.11.052
关键词
tRNA; Translation; Genetic code; Modified nucleosides; Wobble base-pairing; Evolution; Archaea; Bacteria; Eukarya; Mitochondria
资金
- National Science foundation [MCB-05169448]
- National Institutes of Health [R01 GM70641-01]
The strategies organisms use to decode synonymous codons in cytosolic protein synthesis are not uniform. The complete isoacceptor tRNA repertoire and the type of modified nucleoside found at the wobble position 34 of their anticodons were analyzed in all kingdoms of life. This led to the identification of four main decoding strategies that are diversely used in Bacteria, Archaea and Eukarya. Many of the modern tRNA modification enzymes acting at position 34 of tRNAs are present only in specific domains and obviously have arisen late during evolution. In an evolutionary fine-tuning process, these enzymes must have played an essential role in the progressive introduction of new amino acids, and in the refinement and standardization of the canonical nuclear genetic code observed in all extant organisms ( functional convergent evolutionary hypothesis). (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据