期刊
FEBS LETTERS
卷 583, 期 12, 页码 1951-1956出版社
WILEY
DOI: 10.1016/j.febslet.2009.05.033
关键词
Nucleolar protein; RRS1; Aurora B; Sgo1; Centromeric cohesion; Chromosome congression
资金
- MEXT
- Japan Science and Technology Agency
We report here the functional analysis of human Regulator of Ribosome Synthesis 1 (RRS1) protein during mitosis. We demonstrate that RRS1 localizes in the nucleolus during interphase and is distributed at the chromosome periphery during mitosis. RNA interference experiments revealed that RRS1-depleted cells show abnormalities in chromosome alignment and spindle organization, which result in mitotic delay. RRS1 knockdown also perturbs the centromeric localization of Shugoshin 1 and results in premature separation of sister chromatids. Our results suggest that a nucleolar protein RRS1 contributes to chromosome congression. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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