期刊
FEBS LETTERS
卷 583, 期 3, 页码 561-567出版社
WILEY
DOI: 10.1016/j.febslet.2008.12.061
关键词
Human embryonic stem cells; Oligodendrocytes; Vitronectin; Differentiation
资金
- Seoul Research and Business Development Program [10574]
- Korea Science and Engineering Foundation (KOSEF)
- Korea Government (MOST) [R01-2006-000-11364-0]
- National Research Foundation of Korea [R01-2006-000-11364-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that proliferate and differentiate into oligodendrocytes in response to mitogenic and survival factors. These results support the beneficial effect of VN on oligodendrocytic differentiation of hESCs. (c) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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