期刊
FEBS LETTERS
卷 583, 期 7, 页码 1096-1101出版社
WILEY
DOI: 10.1016/j.febslet.2009.03.012
关键词
Rab35; Neurite growth; Cell shape; Actin; Small GTPase; Rac1; RhoA; Cdc42
资金
- Swiss National Science Foundation
- Canadian Institutes for Health Research
- FRSQ Chercheur-Boursier
Recent studies have identified Rab35 in the endocytic pathway and as a regulator of cytokinesis; however its molecular mechanisms are currently unknown. Here, we find that Rab35 colocalizes with actin. laments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro. We find activated Rab35 stimulates neurite outgrowth in PC12 and N1E-115 cells via a Cdc42-dependent pathway and that siRNA knockdown of Rab35 activity abolishes neurite outgrowth in these cell lines. We conclude that one function of Rab35 is to regulate Rho-family GTPases and that this role has consequences for neurite outgrowth.
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