期刊
FEBS LETTERS
卷 583, 期 7, 页码 1132-1140出版社
WILEY
DOI: 10.1016/j.febslet.2009.02.043
关键词
Brain aging; Mitochondria; Pyruvate dehydrogenase; JNK; Neurodegeneration
资金
- NIH [2RO1 AG016718]
Mitochondrial dysfunction is often associated with aging and neurodegeneration. c-Jun-N-terminal kinase (JNK) phosphorylation and its translocation to mitochondria increased as a function of age in rat brain. This was associated with a decrease of pyruvate dehydrogenase (PDH) activity upon phosphorylation of the E-1 alpha subunit of PDH. Phosphorylation of PDH is likely mediated by PDH kinase, the protein levels and activity of which increased with age. ATP levels were diminished, whereas lactic acid levels increased, thus indicating a shift toward anaerobic glycolysis. The energy transduction deficit due to impairment of PDH activity during aging may be associated with JNK signaling. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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