期刊
FEBS LETTERS
卷 583, 期 13, 页码 2157-2159出版社
WILEY
DOI: 10.1016/j.febslet.2009.05.052
关键词
alpha-Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant
资金
- Japan Science and Technology Agency
The major side-effect of treatment with alpha-glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of alpha-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H-2 in the gastrointestinal tract. Acarbose, which is an alpha-glucosidase inhibitor, markedly increased H-2 production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H-2 acts as a unique antioxidant, and that when inhaled or taken orally as H-2-dissolved water it ameliorates ischaemia-reperfusion injury and atherosclerosis development. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据