期刊
FEBS LETTERS
卷 583, 期 4, 页码 759-766出版社
WILEY
DOI: 10.1016/j.febslet.2009.01.034
关键词
MicroRNA-27; Hepatic stellate cell; Fat accumulation; Cell proliferation; Retinoid X receptor alpha; Liver fibrosis
资金
- Natural Science Foundation of China (NSFC) [30570824]
Hepatic stellate cells (HSCs) activation is an initial event in liver. fibrosis. MicroRNAs (miRNAs) have been found to play essential roles in cell differentiation, proliferation, and fat metabolism. In this study, we showed that down-regulation of two over-expressed miRNAs, miR-27a and 27b allowed culture-activated rat HSCs to switch to a more quiescent HSC phenotype, with restored cytoplasmic lipid droplets and decreased cell proliferation. Mechanistically, retinoid X receptor alpha was confirmed to be the target of miR-27a and 27b. These results indicated a new role and mechanism of miR-27a and 27b in regulating fat metabolism and cell proliferation during HSCs activation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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