期刊
FEBS LETTERS
卷 583, 期 15, 页码 2573-2577出版社
WILEY
DOI: 10.1016/j.febslet.2009.07.024
关键词
Short neuropeptide F; Processed peptide; Growth; ERK-insulin pathway; Drosophila
资金
- Korea Science and Engineering Foundation [2008-0061669, 2009-0080870]
- Korea Rural Development Administration [20070401034024]
- KRIBB Research Initiative Program
- National Research Foundation of Korea [2009-0080870, 2008-0061669] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [20070401034024] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The Drosophila sNPF gene regulates growth through the ERK-insulin pathway. sNPF encodes a precursor protein that is processed and produces biologically active sNPF peptides. However, the functions of these peptides are not known. In Drosophila neuronal cells in culture and in flies in vivo, sNPF1 and sNPF2 activated the ERK-insulin pathway and regulated body growth. In addition, the sNPF precursor and the processed sNPF peptide were co-localized in the neurons of the central nervous system. These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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