期刊
FEBS LETTERS
卷 583, 期 15, 页码 2457-2463出版社
WILEY
DOI: 10.1016/j.febslet.2009.07.011
关键词
Adiponectin; Endothelial progenitor cell; Migration; Cdc42; Rac1
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- AGU High-Tech Research Center
- MEXT
- Grants-in-Aid for Scientific Research [21592506] Funding Source: KAKEN
Adiponectin has anti-atherosclerotic effects through its direct actions on vascular cells. The present study investigates the molecular mechanisms of adiponectin in the migration of endothelial progenitor cells (EPCs) which play an important role in neovascularization and re-endothelization. The phosphorylation of Akt and the activations of Cdc42 and Rac1 were significantly increased by adiponectin. Adiponectin increased the migration activity of EPCs, which was completely inhibited by a PI3-kinase inhibitor. siRNA of Cdc42 or Rac1 completely inhibited the adiponectin-induced migration, but siRNA of Akt had no effects, indicating that adiponectin promotes the migration activities of EPCs mainly through PI3-kinase/Cdc42/Rac1.
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