期刊
FEBS LETTERS
卷 583, 期 12, 页码 2077-2082出版社
WILEY
DOI: 10.1016/j.febslet.2009.05.035
关键词
Big brain; Aquaporin-4 (AQP4); Cell adhesion; Drosophila
资金
- MEXT ( Ministry of Education, Culture, Sports, Science and Technology) of Japan
The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in Drosophila neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion and water permeability of Bib. The adhesive function was examined by a cell aggregation assay using L cells. Bib-transfected L cells formed aggregated clusters, while control-L cells remained as a single cell suspension. Ion permeation was not confirmed in L cells stably expressing Bib. When expressed in COS7 cells, Bib exhibited limited water permeability. This newly found cell adhesive function of Bib may be important for Drosophila neurogenesis. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据