期刊
FEBS LETTERS
卷 584, 期 3, 页码 562-566出版社
WILEY
DOI: 10.1016/j.febslet.2009.12.002
关键词
Mitochondria-targeted antioxidant; Multidrug resistance
资金
- Russian Foundation for Basic Research (RFBR) [08-04-01165, 07-04-00-335]
- [N 02.740.11.0097]
A conjugate of plastoquinone with decylrhodamine 19 (SkQR1) selectively accumulates in mitochondria of normal and tumor cells. SkQR1 protected the cellular pool of reduced glutathione under oxidative stress. Overexpression of P-glycoprotein (Pgp 170) multidrug resistance pump strongly suppresses accumulation of SkQR1. The inhibitors of Pgp 170 stimulate accumulation of SkQR1 in various cell lines indicating that SkQR1 is a substrate of Pgp 170. The protective effect of SkQR1 against oxidative stress is diminished in the cells overexpressing Pgp 170. It is suggested that mitochondria-targeted antioxidants could selectively protect normal (Pgp 170-negative) cells against the toxic effect of anti-cancer treatments related to oxidative stress. (C) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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