期刊
FEBS LETTERS
卷 584, 期 1, 页码 81-85出版社
WILEY
DOI: 10.1016/j.febslet.2009.10.086
关键词
AKAP 18 transcript variant; INS-1E cell; siRNA silencing; Insulin secretion; Expression regulation
资金
- European Foundation for the Study of Diabetes (EFSD/Johnson Johnson)
- Novo Nordisk Foundation
- Juvenile Diabetes Research Foundation
A-kinase anchoring proteins (AKAPs) are known to compartmentalise protein kinase(s) to discrete cellular locations. Here we show that silencing of AKAP 18 alpha or gamma expression results in decreased or increased glucose-stimulated insulin secretion in INS-1E cells. Glucose stimulates AKAP 18 alpha and inhibits AKAP 18 gamma mRNA expressions while palmitate markedly reduces AKAP 18 alpha expression. Human growth hormone (GH) stimulates AKAP 18 alpha expression and attenuates palmitate-induced suppression of AKAP 18 alpha mRNA level. The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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