期刊
FEBS LETTERS
卷 583, 期 14, 页码 2414-2418出版社
WILEY
DOI: 10.1016/j.febslet.2009.06.043
关键词
CagA; Virulence factor; Biological half-life; PAR1; Gastric carcinoma; Helicobacter pylori
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
Upon delivery into gastric epithelial cells, Helicobacter pylori cytotoxin-associated gene A (CagA) binds and deregulates cellular proteins such as Src homology 2 domain-containing protein tyrosine phosphatase 2 and partitioning-defective 1 (PAR1), thereby acting as an epigenetic oncoprotein that promotes early phases of gastric cancer development. To elucidate the spatial and temporal contribution of CagA to carcinogenesis, it is crucial to know the stability of CagA in host cells. Here we show that the biological half-life of CagA is about 200 min in gastric epithelial cells. Furthermore, deletion of the PAR1-binding sequence accelerates CagA degradation. Thus, CagA is a relatively short half-life protein whose stability may be modulated through complex formation with PAR1. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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