期刊
FEBS LETTERS
卷 582, 期 5, 页码 573-578出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.01.023
关键词
adipokine; chemerin; insulin signaling; adipocyte differentiation; 3T3-L1 adipocyte; insulin sensitivity
To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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