期刊
FEBS LETTERS
卷 582, 期 25-26, 页码 3577-3584出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.08.038
关键词
Arabidopsis thaliana regulator of G-protein signaling protein 1; Glucose sensing; Heterotrimeric G protein complex; Regulator of G signaling protein 1; Arabidopsis
资金
- NIGMS [GM065989-01]
- DOE [DE-FG02-05ER15671]
- NSF [MCB-0718202, MCB-0723515]
- Max Planck Society
Plants use sugars as signaling molecules and possess mechanisms to detect and respond to changes in sugar availability, ranging from the level of secondary signaling molecules to altered gene transcription. G-protein-coupled pathways are involved in sugar signaling in plants. The Arabidopsis thaliana regulator of G-protein signaling protein 1 (AtRGS1) combines a receptor-like seven transmembrane domain with an RGS domain, interacts with the Arabidopsis G alpha subunit (AtGPA1) in a D-glucose-regulated manner, and stimulates AtGPA1 GTPase activity. We determined that AtRGS1 interacts with additional components, genetically defined here, to serve as a plasma membrane sensor for D-glucose. This interaction between AtRGS1 and AtGPA1 involves, in part, the seven-transmembrane domain of AtRGS1.
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