期刊
FEBS LETTERS
卷 582, 期 5, 页码 543-548出版社
WILEY
DOI: 10.1016/j.febslet.2008.01.019
关键词
SIRT6; sirtuin; calorie restriction; nutrient availability
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM061641, R01 GM061641-10] Funding Source: Medline
Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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