期刊
FEBS LETTERS
卷 582, 期 14, 页码 2004-2016出版社
WILEY
DOI: 10.1016/j.febslet.2008.02.067
关键词
nuclear pore complex; nuclear assembly; cell cycle; nucleoporin
In eukaryotes, all macromolecules traffic between the nucleus and the cytoplasm through nuclear pore complexes (NPCs), which are among the largest supramolecular assemblies in cells. Although their composition in yeast and metazoa is well characterized, understanding how NPCs are assembled and form the pore through the double membrane of the nuclear envelope and how both processes are controlled still remains a challenge. Here, we summarize what is known about the biogenesis of NPCs throughout the cell cycle with special focus on the membrane reorganization and the regulation that go along with NPC assembly. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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