期刊
FEBS LETTERS
卷 582, 期 16, 页码 2371-2376出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.05.044
关键词
NF-kappa B; HSV-1; HSV-1; ICP27; I kappa B alpha
Nuclear factor kappa B (NF-kappa B) is associated with the transcriptional activation of genes encoding chemokines, adhesion molecules, cytokines, and anti-apoptotic proteins, which are key components in immune responses and viral infection. Many viruses modulate NF-kappa B through numerous viral gene products to allow productive infections and immune escape. Here we report that herpes simplex virus-1 infected cell protein 27 (HSV-1 ICP27), an immediate early protein of HSV-1, represses NF-kappa B activity through binding to inhibitor of kappa B (I kappa B alpha), blocking phosphorylation and ubiquitination of I kappa B alpha, and stabilizing I kappa B alpha. These data may explain how NF-kappa B activity is regulated by ICP27 to escape immune responses during the very early period of HSV-1 infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据