期刊
FEBS LETTERS
卷 582, 期 3, 页码 451-456出版社
WILEY
DOI: 10.1016/j.febslet.2007.12.037
关键词
adiponectin; AMP-activated protein kinase; calcium signaling; osteoclastogenesis; receptor activator of nuclear factor-kappa B ligand; nuclear factor of activated T cells c1
We investigated here whether adiponectin can exhibit an inhibitory effect on tumor necrosis factor-alpha (TNF-alpha)- and receptor activator of nuclear factor-kappa B ligand (RANKL)induced osteoclastogenesis by using RAW264 cell D clone with a high efficiency to form osteoclasts. Globular adiponectin (gAd) strongly inhibited TNF-alpha/RANKL-induced differentiation of osteoclasts by interfering with TNF receptor-associated factor 6 production and calcium signaling; consequently, the induction of nuclear factor of activated T cells c1 (NFATc1) was strongly inhibited. Moreover, we observed that inhibition of AMP-activated protein kinase abrogated gAd inhibition for TNF-alpha/RANKL-induced NFATc1 expression. Our data suggest that adiponectin acts as a potent regulator of bone resorption observed in diseases associated with cytokine activation. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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