Ascorbic acid is a regulator of the intracellular cAMP concentration: Old molecule, new functions?

Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid ( AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues. (c) 2008 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.