期刊
FEBS LETTERS
卷 582, 期 9, 页码 1391-1394出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.03.022
关键词
phosphoinositide; tyrosine kinase; RNA interference; PtdIns5P
资金
- Biotechnology and Biological Sciences Research Council [BB/C514074/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/C514074/1] Funding Source: Medline
Cellular levels of the phosphoinositide PtdIns5P are regulated by agonist stimulation, but the mechanisms controlling turnover of this lipid, and the subcellular location of the regulated PtdIns5P pool(s), remain poorly understood. Here we show that enhanced tyrosine phosphorylation robustly increases cellular PtdIns5P levels. Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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