期刊
FEBS LETTERS
卷 582, 期 16, 页码 2345-2351出版社
WILEY
DOI: 10.1016/j.febslet.2008.06.006
关键词
cyclophilin; FKBP; spliceosome; cyclosporin; FK506; small nuclear RNAs
资金
- NIGMS NIH HHS [SC1 GM083685, SC1 GM083685-01] Funding Source: Medline
The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidylprolyl cis-trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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