期刊
FEBS LETTERS
卷 582, 期 16, 页码 2453-2457出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.06.010
关键词
RanBPM; RanBP9; mGlu2; mGlu8b; protein interaction; retina
In the central nervous system, synaptic signal transduction depends on the regulation of neurotransmitter receptors by interacting proteins. Here, we searched for proteins interacting with two metabotropic glutamate receptor type 8 isoforms (mGlu8a and mGlu8b) and identified RanBPM. RanBPM is expressed in several brain regions, including the retina. There, RanBPM is restricted to the inner plexiform layer where it colocalizes with the mGlu8b isoform and processes of cholinergic amacrine cells expressing mGlu2 receptors. RanBPM interacts with mGlu2 and other group II and group III receptors, except mGlu6. Our data suggest that RanBPM might be associated with mGlu receptors at synaptic sites. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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