期刊
FEBS LETTERS
卷 582, 期 13, 页码 1809-1815出版社
WILEY
DOI: 10.1016/j.febslet.2008.04.045
关键词
apoptosis; 11 beta-hydroxysteroid dehydrogenase type 1; hexose-6-phosphate dehydrogenase; glucose-6-phosphate transporter; glucocorticoid
The present study demonstrates the expression of hexose-6-phosphate dehydrogenase and 11 beta-hydroxysteroid dehydrogenase type 1 in human neutrophils, and the presence and activity of these enzymes in the microsomal fraction of the cells. Their concerted action together with the previously described glucose-6-phosphate transporter is responsible for cortisone-cortisol interconversion detected in human neutrophils. Furthermore, the results suggest that luminal NADPH generation by the cortisol dehydrogenase activity of 11 beta-hydroxysteroid dehydrogenase type 1 prevents neutrophil apoptosis provoked by the inhibition of the glucose-6-phosphate transporter. In conclusion, the maintenance of the luminal NADPH pool is an important antiapoptotic factor in neutrophil granulocytes. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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