期刊
FEBS LETTERS
卷 582, 期 13, 页码 1821-1828出版社
WILEY
DOI: 10.1016/j.febslet.2008.04.046
关键词
butein; NF-kappa B; invasion; epithelial-mesenchymal transition (EMT); bladder cancer
There is increasing evidence that epithelial-mesenchymal transition (EMT) plays a critical role in cancer metastasis. Butein is a polyphenolic compound, which has been found to exhibit anti-proliferation effects on cancer cells. Here, we report that in addition to its function as an anti-proliferation agent, butein can inhibit migration and invasion through the ERK1/2 and NF-kappa B signaling pathways in human bladder cancer cells, and this inhibitory effect may be associated with reversal of EMT. These results were further confirmed by RNAi-mediated suppression of NF-kappa B, which partly reverses EMT and inhibits cell invasive ability in vitro. These results suggest a novel function of butein as an invasion inhibitor in bladder cancer. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据