期刊
FEBS LETTERS
卷 582, 期 12, 页码 1667-1671出版社
WILEY
DOI: 10.1016/j.febslet.2008.04.021
关键词
alpha-lipoic acid (alpha-LA); reactive oxygen species (ROS); apoptosis; caspase; PTEN, Akt (PKB)
We report here that alpha-lipoic acid (alpha-LA), a naturally-occurring antioxidant, scavenges reactive oxygen species (ROS) followed by an increase in apoptosis of human hepatoma cells. Apoptosis induced by alpha-LA was dependent upon the activation of the caspase cascade and the mitochondrial death pathway. alpha-LA induced increases in caspase-9 and caspase-3 but had no significant effect on caspase-8 activity. Apoptosis induced by alpha-LA was found to be mediated through the tensin homologue deleted on chromosome 10 (PTEN)/Akt pathway. Prior to cell apoptosis, PTEN was activated and its downstream target Akt was inhibited. Our findings indicate that increasing ROS scavenging could be a therapeutic strategy to treat cancer. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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