期刊
FEBS LETTERS
卷 582, 期 10, 页码 1451-1458出版社
WILEY
DOI: 10.1016/j.febslet.2008.03.030
关键词
osteoactivin; osteoclast; bone resorption; fusion; spreading; integrin
This study presents gene expression, protein expression, and in situ immunohistochemical evidence that osteoclasts express high levels of osteoactivin (OA), which had previously been reported to be an osteoblast-specific protein in bone. OA expression in osteoclasts was up-regulated upon receptor activator of NF kappa B ligand-induced differentiation. Suppression of functional activity of OA with neutralizing antibody reduced cell size, number of nuclei, fusion, and bone resorption activity of osteoclasts. OA was co-immunoprecipitated with integrin beta(3) and beta(1), indicating that OA co-localizes with integrin beta(3) and/or beta(1) in a hetero-polymeric complex in osteoclasts. These findings indicate that OA is a novel osteoclastic protein and plays a role in osteoclast differentiation and/or activity. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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