期刊
FEBS LETTERS
卷 583, 期 1, 页码 7-12出版社
WILEY
DOI: 10.1016/j.febslet.2008.12.005
关键词
Phagocyte; Respiratory burst; pH; Ion channel; Gating; Leukocyte
资金
- Schmidtmann Foundation
- Heart, Lung and Blood Institutes of Health [HL61437]
- Philip Morris USA Inc.
- Philip Morris International
Voltage gated proton channels and NADPH oxidase function cooperatively in phagocytes during the respiratory burst, when reactive oxygen species are produced to kill microbial invaders. Although these molecules are distinct entities, with no proven physical interaction, their presence and activity in many cells appears to be coordinated. We describe these interactions and discuss several types of mechanisms that might explain them. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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