期刊
FEBS LETTERS
卷 582, 期 27, 页码 3811-3816出版社
WILEY
DOI: 10.1016/j.febslet.2008.10.016
关键词
Transporter; Membrane bound; SLC; Phylogeny; Repertoire; Orphan
资金
- Swedish Research Council
- Svenska Lakaresallskapet, Ahlens Foundation
- Lars Hiertas foundation
- Gunvor and Josef Aners Foundation
- The Royal Swedish Academy of Sciences
- Tore Nilsson foundation
- Novo Nordisk Foundation
- Magnus Bergvall Foundation
Solute carriers (SLCs) is the largest group of transporters, embracing transporters for inorganic ions, amino acids, neurotransmitters, sugars, purines and fatty acids among other substrates. We mined the finished assembly of the human genome using Hidden Markov Models (HMMs) obtaining a total of 384 unique SLC sequences. Detailed clustering and phylogenetic analysis of the entire SLC family showed that 15 of the families place into four large phylogenetic clusters with the largest containing eight SLC families, suggesting that many of the distinct families of SLCs have a common evolutionary origin. This study represents the first overall genomic roadmap of the SLCs providing large sequence sets and clarifies the phylogenetic relationships among the families of the second largest group of membrane proteins. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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