期刊
FEBS LETTERS
卷 582, 期 15, 页码 2309-2312出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.05.035
关键词
agglutinin; lectin; mistletoe; ribosome-inactivating protein; ricin
Mistletoe lectin is a potent biohazard. Lectin activity in the toxic dimer primarily originates from the 2 gamma-subdomain (Tyr-site) of the B-subunit. Crystallographic information on lectin-sugar complexes is available only at acidic pH, where lectin activity is low. Thus, we mapped ligand-binding properties including comparison to ricin's Tyr-site at neutral pH. Using these results and molecular dynamics simulations, a local conformational change was rendered likely. The obtained structural information is valuable for the design of potent inhibitors. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据