期刊
FEBS LETTERS
卷 582, 期 23-24, 页码 3396-3400出版社
WILEY
DOI: 10.1016/j.febslet.2008.08.035
关键词
Acute cerebral ischemia; Experimental therapy; Neuroprotection; Nuclear receptor; Transcriptional activator
资金
- American Diabetes Association
- American Heart Association
Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据