期刊
FEBS JOURNAL
卷 281, 期 15, 页码 3420-3432出版社
WILEY
DOI: 10.1111/febs.12870
关键词
metabolic channeling; protein interaction network; robustness; self-assembly
资金
- National Science Foundation [DBI-0845196, IOS-1126992]
- Reproductive Biology Group of the Food for the 21st Century program at the University of Missouri
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1126992] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0845196] Funding Source: National Science Foundation
The organization of the cellular interior gives rise to properties including metabolic channeling and micro-compartmentalization of signaling. Here, we use a lattice model of molecular crowding, together with literature-derived protein interactions and abundances, to describe the molecular organization and stoichiometry of local cellular regions, showing that physical protein-protein interactions induce emergent structures not seen when random interaction networks are modeled. Specifically, we find that the lattices give rise to micro-groups of enzymes on the surfaces of protein clusters. These arrangements of proteins are also robust to protein overexpression, while still showing evidence for expression tuning. Our results indicate that some of the complex organization of the cell may derive from simple rules of molecular aggregation and interaction.
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