期刊
FEBS JOURNAL
卷 280, 期 17, 页码 4118-4130出版社
WILEY
DOI: 10.1111/febs.12166
关键词
inflammation; macrophages; monocytes; myogenic precursor cells; skeletal muscle
资金
- Agence Nationale de la Recherche
- European Union (FP7)
- Association Francaise contre les Myopathies
- Agence Nationale de Lutte contre le Dopage
- Societe Francaise de Myologie
Adult skeletal muscle has the remarkable property of regenerating after damage, owing to satellite cells and myogenic precursor cells becoming committed to adult myogenesis to rebuild the muscle. This process is accompanied by the continuing presence of macrophages, from the phagocytosis of damaged myofibres to the full re-formation of new myofibres. In recent years, there has been huge progress in our understanding of the roles of macrophages during skeletal muscle regeneration, notably concerning their effects on myogenic precursor cells. Here, we review the most recent knowledge acquired on monocyte entry into damaged muscle, the various macrophage subpopulations, and their respective roles during the sequential phases of muscle repair. We also discuss the role of macrophages after exercise-induced muscle damage, notably in humans.
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