期刊
FEBS JOURNAL
卷 280, 期 5, 页码 1169-1199出版社
WILEY
DOI: 10.1111/febs.12114
关键词
cytokinin; pathogenesis; phytohormones; plant allergen; PR-10; proteinligand binding
资金
- Ministry of Science and Higher Education [N N301 003739]
Physical, chemical and biological stress factors, such as microbial infection, upregulate the transcription levels of a number of plant genes, coding for the so-called pathogenesis-related (PR) proteins. For PR proteins of class-10 (PR-10), the biological function remains unclear, despite two decades of scientific research. PR-10 proteins have a wide distribution throughout the plant kingdom and the class members share size and secondary structure organization. Throughout the years, we and other groups have determined the structures of a number of PR-10 proteins, both in the crystalline state by X-ray diffraction and in solution by NMR spectroscopy. Despite the accumulating structural information, our understanding of PR-10 function is still limited. PR-10 proteins are rather small (160 amino acids) with a fold consisting of three helices and seven antiparallel strands. These structural elements enclose a large hydrophobic cavity that is most probably the key to their functional relevance. Also, the outer surface of these proteins is of extreme interest, as epitopes from a PR-10 subclass cause allergic reactions in humans.
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