期刊
FEBS JOURNAL
卷 281, 期 1, 页码 416-429出版社
WILEY
DOI: 10.1111/febs.12611
关键词
cavity volume calculation; ligand-binding cavity; plant pathogenesis-related proteins; protein squeezing; protein stretching
资金
- European Regional Development Fund under the Operational Programme Innovative Economy NanoFun [POIG.02.02.00-00-025/09]
- Polish National Science Centre [2011/01/B/ST3/02190]
- Ministry of Science and Higher Education [NN 301 003739]
- [FiberFuel ERA-NET-IB/06/2013/]
We provide theoretical comparisons of the physical properties of eighteen proteins with the pathogenesis-related proteins of class 10 (PR-10) fold, which is characterized by a large hydrophobic cavity enclosed between a curved -sheet and a variable -helix. Our novel algorithm to calculate the volume of internal cavities within protein structures is used to demonstrate that, although the sizes of the cavities of the investigated PR-10 proteins vary significantly, their other physical properties, such as thermodynamic and mechanical parameters or parameters related to folding, are very close. The largest variations (in the order of 20%) are predicted for the optimal folding times. We show that, on squeezing, the PR-10 proteins behave differently from typical virus capsids.
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