相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Patrick S. Ward et al.
CANCER CELL (2012)
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
William A. Freed-Pastor et al.
CELL (2012)
Mechanisms for Insulin Resistance: Common Threads and Missing Links
Varman T. Samuel et al.
CELL (2012)
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
Celia Quijano et al.
CELL CYCLE (2012)
Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Fatty Acid Metabolism
Jurre J. Kamphorst et al.
ANALYTICAL CHEMISTRY (2011)
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
Lisa S. Pike et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2011)
A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
Amy K. Walker et al.
CELL (2011)
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Yu Li et al.
CELL METABOLISM (2011)
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway
Liudmila L. Kodach et al.
GUT (2011)
pH Control Mechanisms of Tumor Survival and Growth
Scott K. Parks et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study
Thomas P. Ahern et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
Deliang Guo et al.
CANCER DISCOVERY (2011)
Defining the pathway to insulin-like growth factor system targeting in cancer
Steven A. Rosenzweig et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Adipose tissue pathways involved in weight loss of cancer cachexia
I. Dahlman et al.
BRITISH JOURNAL OF CANCER (2010)
Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer Cells
Egidio Iorio et al.
CANCER RESEARCH (2010)
De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman et al.
CANCER RESEARCH (2010)
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
Daniel K. Nomura et al.
CELL (2010)
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
Eek Joong Park et al.
CELL (2010)
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
Tina Gimm et al.
FASEB JOURNAL (2010)
Effect of statin therapy on colorectal cancer
Marc Bardou et al.
GUT (2010)
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
Ismael Samudio et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
Vanessa Fritz et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
The genetic basis of kidney cancer: a metabolic disease
W. Marston Linehan et al.
NATURE REVIEWS UROLOGY (2010)
Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells
Daniel Hess et al.
PLOS ONE (2010)
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
Shijie Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Dysregulation of the mevalonate pathway promotes transformation
James W. Clendening et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Lipid Rafts As a Membrane-Organizing Principle
Daniel Lingwood et al.
SCIENCE (2010)
Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation
Awad Shamma et al.
CANCER CELL (2009)
Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism
Kenji Tamura et al.
CANCER RESEARCH (2009)
Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism
Yukie Yoshii et al.
CANCER SCIENCE (2009)
Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
Robert V. Farese et al.
CELL (2009)
Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy
Jaya Krishnan et al.
CELL METABOLISM (2009)
Statins Are Associated With a Reduced Risk of Hepatocellular Carcinoma in a Large Cohort of Patients With Diabetes
Hashem B. El-Serag et al.
GASTROENTEROLOGY (2009)
A Phosphorylation Cascade Controls the Degradation of Active SREBP1
Maria T. Bengoechea-Alonso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism
Erinn B. Rankin et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany et al.
NATURE (2009)
Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
Natalia Scaglia et al.
PLOS ONE (2009)
Differential Role of Human Choline Kinase α and β Enzymes in Lipid Metabolism: Implications in Cancer Onset and Treatment
David Gallego-Ortega et al.
PLOS ONE (2009)
Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion
J. Khasawneh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
Deliang Guo et al.
SCIENCE SIGNALING (2009)
Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
Gregory A. Locke et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
Lipolysis -: Not inflammation, cell death, or lipogenesis -: Is involved in adipose tissue loss in cancer cachexia
Mikael Ryden et al.
CANCER (2008)
Tumor cell metabolism: Cancer's Achilles' heel
Guido Kroemer et al.
CANCER CELL (2008)
Evidence for an Important Role of CIDEA in Human Cancer Cachexia
Jurga Laurencikiene et al.
CANCER RESEARCH (2008)
Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells
Maria T. Accioly et al.
CANCER RESEARCH (2008)
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Eiji Furuta et al.
CANCER RESEARCH (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Cachexia: A new definition
William J. Evans et al.
CLINICAL NUTRITION (2008)
Chemoembolization Combined with Pravastatin Improves Survival in Patients with Hepatocellular Carcinoma
Hannah Graf et al.
DIGESTION (2008)
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
William G. Kaelin et al.
MOLECULAR CELL (2008)
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
NATURE REVIEWS CANCER (2008)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Up-regulation of Acetyl-CoA carboxylase α and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
Sarah Yoon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Chemical inhibition of Acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
Annelies Beckers et al.
CANCER RESEARCH (2007)
Statins and the risk of colorectal cancer: A meta-analysis of 18 studies involving more than 1.5 million patients
Stefanos Bonovas et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
Panagiotis A. Konstantinopoulos et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Mechanism of increased lipolysis in cancer cachexia
Thorhallur Agustsson et al.
CANCER RESEARCH (2007)
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gaorav P. Gupta et al.
NATURE (2007)
SREBP in signal transduction: cholesterol metabolism and beyond
Maria T. Bengoechea-Alonso et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Targeted inactivation of Fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
Patrick J. Pollard et al.
CANCER CELL (2007)
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth
Ralph J. DeBerardinis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Obesity and cancer risk: the role of the insulin-IGF axis
Andrew G. Renehan et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
Fajun Yang et al.
NATURE (2006)
Hypoxia converts human macrophages into triglyceride-loaded foam cells
Pontus Bostrom et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis
Maria T. Bengoechea-Alonso et al.
CELL CYCLE (2006)
Inflammation and insulin resistance
Steven E. Shoelson et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
The role of cholesterol in prostate cancer
Martin H. Hager et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2006)
The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots
Leslie C. Costello et al.
MOLECULAR CANCER (2006)
Mitochondrial NADPH, transhydrogenase and disease
Jan Rydstrom
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
M Cully et al.
NATURE REVIEWS CANCER (2006)
Statins and cancer risk - A meta-analysis
KM Dale et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
Y. Liu
PROSTATE CANCER AND PROSTATIC DISEASES (2006)
ATP citrate lyase inhibition can suppress tumor cell growth
G Hatzivassiliou et al.
CANCER CELL (2005)
ATP citrate lyase is an important component of cell growth and transformation
DE Bauer et al.
ONCOGENE (2005)
Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells
N Scaglia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis
A Ramírez de Molina et al.
CANCER RESEARCH (2005)
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
M Buzzai et al.
ONCOGENE (2005)
Peroxisomal branched chain fatty acid β-oxidation pathway is upregulated in prostate cancer
S Zha et al.
PROSTATE (2005)
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCFFbw7
A Sundqvist et al.
CELL METABOLISM (2005)
Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy
SM Sebti
CANCER CELL (2005)
High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts
N Scaglia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
P Dobrzyn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
EE Calle et al.
NATURE REVIEWS CANCER (2004)
SREBP transcription factors:: master regulators of lipid homeostasis
D Eberlé et al.
BIOCHIMIE (2004)
The SREBP pathway - Insights from insigs and insects
RB Rawson
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
The emerging role of lysophosphatidic acid in cancer
GB Mills et al.
NATURE REVIEWS CANCER (2003)
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
JD Horton
BIOCHEMICAL SOCIETY TRANSACTIONS (2002)
Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats
FS Falvella et al.
CARCINOGENESIS (2002)
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
DC Berwick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
PJ Espenshade et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
A Ramírez de Molina et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Going malignant: the hypoxia-cancer connection in the prostate
PW Hochachka et al.
BIOESSAYS (2002)
Comparison of [18F]fluorocholine and [18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer
DT Price et al.
JOURNAL OF UROLOGY (2002)
Increased choline kinase activity in human breast carcinomas:: clinical evidence for a potential novel antitumor strategy
AR de Molina et al.
ONCOGENE (2002)
Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila
IY Dobrosotskaya et al.
SCIENCE (2002)
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis:: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
E Laughner et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia
JN Li et al.
EXPERIMENTAL CELL RESEARCH (2000)
Lipid rafts and signal transduction
K Simons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)