期刊
FEBS JOURNAL
卷 279, 期 19, 页码 3549-3558出版社
WILEY
DOI: 10.1111/j.1742-4658.2012.08729.x
关键词
cell polarity; cytokinesis; discs large; DLG isoforms; membrane associated guanylate kinase; midbody; PDZ; viral oncoproteins
资金
- Cancer Research UK [C427/A3919, C427/A8049]
- Wellcome Trust [093450/Z/10/Z]
- Wellcome Trust [093450/Z/10/Z] Funding Source: Wellcome Trust
Discs-large (DLG) is a multi-PDZ domain-containing protein that belongs to the family of molecular scaffolding proteins known as membrane guanylate kinases or MAGUKs. DLG is a component of the Scribble polarity complex and genetic analyses of DLG in Drosophila have identified a role for the protein in several key biological processes including the regulation of apico-basal polarity of epithelial cells, as well as other polarity processes such as asymmetric cell division and cell invasion. Disturbance of DLG function leads to uncontrolled epithelial cell proliferation and neoplastic transformation, thereby defining DLG as a potential tumour suppressor. However, whether mammalian homologues of DLG (DLG1, DLG2, DLG3 and DLG4) also possess tumour suppressor functions is not known. In this minireview, we focus on the biological functions of DLG1 in human epithelial cells and on how the function of this MAGUK relates to its intracellular location. We examine some of the evidence that implies that DLG has both tumour suppressor and, paradoxically, oncogenic functions depending upon the precise cellular context.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据