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Human Cancer-Associated Mutations in the Aα Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in Aα Knock-In and Knockout Mice
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MOLECULAR CANCER (2011)
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MOLECULAR CELL (2011)
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α4 is highly expressed in carcinogen-transformed human cells and primary human cancers
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The Peptidyl Prolyl Isomerase Rrd1 Regulates the Elongation of RNA Polymerase II during Transcriptional Stresses
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mice lacking phosphatase PP2A subunit PR61/B′δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Control of mTORC1 signaling by the Opitz syndrome protein MID1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases
Sven Ivar Walaas et al.
FRONTIERS IN NEUROANATOMY (2011)
Alpha4 Is a Ubiquitin-Binding Protein That Regulates Protein Serine/Threonine Phosphatase 2A Ubiquitination
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Animal models reveal role for tau phosphorylation in human disease
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Rrd1 isomerizes RNA polymerase II in response to rapamycin
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BMC MOLECULAR BIOLOGY (2010)
Identification of PP2A Complexes and Pathways Involved in Cell Transformation
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CANCER RESEARCH (2010)
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FASEB JOURNAL (2010)
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α4 Phosphoprotein Interacts With EDD E3 Ubiquitin Ligase and Poly(A)-Binding Protein
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JOURNAL OF CELLULAR BIOCHEMISTRY (2010)
Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling
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MOLECULAR CELL (2010)
Functions of B56-containing PP2As in major developmental and cancer signaling pathways
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LIFE SCIENCES (2010)
Live-cell imaging RNAi screen identifies PP2A-B55α and importin-β1 as key mitotic exit regulators in human cells
Michael H. A. Schmitz et al.
NATURE CELL BIOLOGY (2010)
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A-Mediated Inactivation in Human Malignant Glioma
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CANCER RESEARCH (2009)
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The 48-kDa Alternative Translation Isoform of PP2A:B56ε Is Required for Wnt Signaling during Midbrain-Hindbrain Boundary Formation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein
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MOLECULAR CELL (2009)
α4 Is an Essential Regulator of PP2A Phosphatase Activity
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MOLECULAR CELL (2009)
An integrated workflow for charting the human interaction proteome: insights into the PP2A system
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MOLECULAR SYSTEMS BIOLOGY (2009)
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BIOCHEMISTRY (2008)
Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B subunits of protein phosphatase 2A
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BMC GENOMICS (2008)
A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins
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Structural mechanism of demethylation and inactivation of protein phosphatase 2A
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CELL (2008)
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling
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Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4
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Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A Bα Subunit Expression That Correlate with Enhanced Tau Phosphorylation
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MOLECULAR CELL (2008)
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PLOS ONE (2008)
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Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, α4 and the mammalian ortholog of yeast Tip41 (TIPRL)
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FEBS JOURNAL (2007)
Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The PP2A-associated protein α4 plays a critical role in the regulation of cell spreading and migration
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Selection of protein phosphatase 2A regulatory Subunits is mediated by the C terminus of the catalytic subunit
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway
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ONCOGENE (2007)
The structure of Tap42/α4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation
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BIOCHEMISTRY (2007)
The tumor suppressor PP2A Aβ regulates the RaIA GTPase
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CELL (2007)
Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephospholylation of MEK3
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Generation of active protein phosphatase 2A is coupled to holoenzyme assembly
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PLOS BIOLOGY (2007)
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
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Large-scale mapping of human protein-protein interactions by mass spectrometry
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Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1α binding to PIAS1
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Emerging roles of nuclear protein phosphatases
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Structure of the protein phosphatase 2A holoenzyme
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CELL (2006)
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CELL (2006)
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MOLECULAR CELL (2006)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1
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EMBO JOURNAL (2006)
Crystal structure of the PP2A phosphatase activator: Implications for its PP2A-specific PPlase activity
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MOLECULAR CELL (2006)
Low resolution structure of the human α4 protein (IgBP1) and studies on the stability of α4 and of its yeast ortholog Tap42
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The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure
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Involvement of PP2A in viral and cellular transformation
JD Arroyo et al.
ONCOGENE (2005)
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity
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MOLECULAR & CELLULAR PROTEOMICS (2005)
The heterodimer of α4 and PP2Ac is associated with S6 kinase1 in B cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The yeast phosphotyrosyl phosphatase activator is part of the tap42-phosphatase complexes
Y Zheng et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2
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BIOCHEMICAL JOURNAL (2005)
PP2A: the expected tumor suppressor
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CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)
Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity
N Leulliot et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B′ regulatory subunits of protein phosphatase 2A in mice
E Martens et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Overlapping binding sites in protein phosphatase 2A for association with regulatory A and α-4 (mTap42) subunits
TD Prickett et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA
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CURRENT GENETICS (2004)
The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis
R Koren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival
S Strack et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The PP2A-associated protein α4 is an essential inhibitor of apoptosis
M Kong et al.
SCIENCE (2004)
An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator
S Longin et al.
BIOCHEMICAL JOURNAL (2004)
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
E Sontag et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)
Global analysis of protein expression in yeast
S Ghaemmaghami et al.
NATURE (2003)
Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2AC, PP4C, and PP6C) and analysis of the interaction of PP2AC with alpha4 protein
S Kloeker et al.
PROTEIN EXPRESSION AND PURIFICATION (2003)
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T Fellner et al.
GENES & DEVELOPMENT (2003)
A developmentally regulated, neuron-specific splice variant of the variable subunit Bβ targets protein phosphatase 2A to mitochondria and modulates apoptosis
RK Dagda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
T cell-specific gene targeting reveals that α4 is required for early T cell development
DR Hua et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
The MID1/PP2A complex: a key to the pathogenesis of Opitz BBB/G syndrome
S Schweiger et al.
BIOESSAYS (2003)
Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases
HM Wang et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A
K Schmidt et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle
MS Gentry et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B′ subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest
DA Bennin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster
XH Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease
SB Vafai et al.
FEBS LETTERS (2002)
Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits
AM Silverstein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation
S Inui et al.
INTERNATIONAL IMMUNOLOGY (2002)
MID1 and MID2 homo- and hetero-dimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders
KM Short et al.
BMC CELL BIOLOGY (2002)
MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation
A Trockenbacher et al.
NATURE GENETICS (2001)
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway
E Jacinto et al.
MOLECULAR CELL (2001)
Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4
J Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations
C Van Hoof et al.
EXPERIMENTAL CELL RESEARCH (2001)
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
V Janssens et al.
BIOCHEMICAL JOURNAL (2001)
The phosphotyrosyl phosphatase activator, ncs1p (Rrd1p), functions with cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae
DA Mitchell et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
J Wu et al.
EMBO JOURNAL (2000)
The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle
C Van Hoof et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres
CJ Hastie et al.
BIOCHEMICAL JOURNAL (2000)
Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae
B Rempola et al.
MOLECULAR AND GENERAL GENETICS (2000)
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