4.6 Review

MicroRNAs and cardiovascular diseases

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Conditional Dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling

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MiR-126 regulates angiogenic signaling and vascular integrity

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MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3

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MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

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Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

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An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

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MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression

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Altered microRNA expression in human heart disease

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An mRNA m7G cap binding-like motif within human Ago2 represses translation

Marianthi Kiriakidou et al.

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Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy

Mariko Tatsuguchi et al.

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MicroRNA-133 controls cardiac hypertrophy

Alessandra Care et al.

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Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells

Yajaira Suarez et al.

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Control of stress-dependent cardiac growth and gene expression by a microRNA

Eva van Rooij et al.

SCIENCE (2007)

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MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts

Jiening Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

Baofeng Yang et al.

NATURE MEDICINE (2007)

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MicroRNAs play an essential role in the development of cardiac hypertrophy

Danish Sayed et al.

CIRCULATION RESEARCH (2007)

Article Physiology

MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy

John J. McCarthy et al.

JOURNAL OF APPLIED PHYSIOLOGY (2007)

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MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia

Zhong Hua et al.

PLOS ONE (2006)

Article Multidisciplinary Sciences

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Eva van Rooij et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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MicroRNAs modulate the angiogenic properties of HLTVECs

Laura Poliseno et al.

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Gene regulatory networks in the evolution and development of the heart

Eric N. Olson

SCIENCE (2006)

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Making or breaking the heart: From lineage determination to morphogenesis

Deepak Srivastava

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Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

Michael Dews et al.

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MicroRNA1 influences cardiac differentiation in Drosophila and regulates notch signaling

C Kwon et al.

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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

DT Humphreys et al.

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miR-15 and miR-16 induce apoptosis by targeting BCL2

A Cimmino et al.

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Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

CL Jopling et al.

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

S Bagga et al.

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MicroRNAs regulate brain morphogenesis in zebrafish

AJ Giraldez et al.

SCIENCE (2005)

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Dicer is required for embryonic angiogenesis during mouse development

WJ Yang et al.

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Phylogenetic shadowing and computational identification of human microRNA genes

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Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

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Dicer is essential for mouse development

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Sizing up the heart: development redux in disease

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Gene expression in fibroblasts and fibrosis - Involvement in cardiac hypertrophy

I Manabe et al.

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E Marbán

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DYR Stainier

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Connexin expression and turnover - Implications for cardiac excitability

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