期刊
FEBS JOURNAL
卷 278, 期 10, 页码 1619-1633出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1742-4658.2011.08090.x
关键词
angiogenesis; arrhythmia; cardiac development; fibrosis; heart failure; hypertrophy; metabolic syndrome; myocardial infarction
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- NIH [AI068896]
- Grants-in-Aid for Scientific Research [23390211] Funding Source: KAKEN
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovascular system under some pathological conditions. Gain- and loss-of-function studies using in vitro and in vivo models have revealed distinct roles for specific miRNAs in cardiovascular development and physiological function. The implications of miRNAs in cardiovascular disease have recently been recognized, representing the most rapidly evolving research field. In the present minireview, the current relevant findings on the role of miRNAs in cardiac diseases are updated and the target genes of these miRNAs are summarized.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据