期刊
FEBS JOURNAL
卷 278, 期 18, 页码 3256-3276出版社
WILEY
DOI: 10.1111/j.1742-4658.2011.08275.x
关键词
antinociception; biomarker; dipeptidyl peptidase; gluzincin; M49 family; opioids; ortholog; oxidative stress; peptidome; tynorphin
资金
- Indian Council of Medical Research (ICMR), New Delhi, India
- Defense Research and Development Organization (DRDO), Government of India, New Delhi
Dipeptidyl peptidase III (DPP III), the sole member and representative of the M49 family of metallopeptidases, is a zinc-dependent aminopeptidase. It sequentially hydrolyses dipeptides from the N-terminal of oligopeptides ranging from three to 10 amino acid residues. Although implicated in an array of pathophysiological phenomena, the precise function of this peptidase is still unclear. However, a number of studies advocate its contribution in terminal stages of protein turnover. Altered expression of DPP III which suggests its involvement in primary ovarian carcinoma, oxidative stress (Nrf2 nuclear localization), pain, inflammation and cataractogenesis has recently led to resurgence of interest in delineating the role of the peptidase in these pathophysiological processes. This review article intends to bring forth the latest updates in this arena which may serve as a base for future studies on the peptidase.
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