期刊
FEBS JOURNAL
卷 278, 期 5, 页码 687-703出版社
WILEY
DOI: 10.1111/j.1742-4658.2011.08004.x
关键词
HSQC; nuclear magnetic resonance (NMR) spectroscopy; protein folding; protein NMR spectroscopy; protein stability; protein structure determination; TROSY
资金
- Queensland Smart State Research Facilities Fund
- Australian Research Council [DP0774245, DP1095728, DP0879121]
- Australian Research Council [DP0879121, DP0774245] Funding Source: Australian Research Council
NMR spectroscopy is a powerful tool for studying the structure, function and dynamics of biological macromolecules. However, non-spectroscopists often find NMR theory daunting and data interpretation nontrivial. As the first of two back-to-back reviews on NMR spectroscopy aimed at non-spectroscopists, the present review first provides an introduction to the basics of macromolecular NMR spectroscopy, including a discussion of typical sample requirements and what information can be obtained from simple NMR experiments. We then review the use of NMR spectroscopy for determining the 3D structures of macromolecules and examine how to judge the quality of NMR-derived structures.
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