期刊
FEBS JOURNAL
卷 277, 期 8, 页码 1805-1821出版社
WILEY
DOI: 10.1111/j.1742-4658.2010.07607.x
关键词
ASH1; ASH2; COMPASS; histone H3 lysine 4; histone methyltransferase; MLL; Set1; TAC1; TRX; WDR5
资金
- National Institutes of Health [1R15GM088798-01]
- American Heart Association [0635008N]
- American Cancer Society [06-52]
- Mallinckrodt Foundation
- Southern Illinois University
The fourth lysine of histone H3 is post-translationally modified by a methyl group via the action of histone methyltransferase, and such a covalent modification is associated with transcriptionally active and/or repressed chromatin states. Thus, histone H3 lysine 4 methylation has a crucial role in maintaining normal cellular functions. In fact, misregulation of this covalent modification has been implicated in various types of cancer and other diseases. Therefore, a large number of studies over recent years have been directed towards histone H3 lysine 4 methylation and the enzymes involved in this covalent modification in eukaryotes ranging from yeast to human. These studies revealed a set of histone H3 lysine 4 methyltransferases with important cellular functions in different eukaryotes, as discussed here.
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