期刊
FEBS JOURNAL
卷 277, 期 5, 页码 1126-1144出版社
WILEY
DOI: 10.1111/j.1742-4658.2009.07526.x
关键词
cancer; dipeptidyl peptidase; distribution; enzyme; extracellular matrix; immune function; liver fibrosis; structure
资金
- National Health and Medical Research Council of Australia
- DMTY
- Australian Postgraduate Awards
Of the 600+ known proteases identified to date in mammals, a significant percentage is involved or implicated in pathogenic and cancer processes. The dipeptidyl peptidase IV (DPIV) gene family, comprising four enzyme members [DPIV (EC 3.4.14.5), fibroblast activation protein, DP8 and DP9] and two nonenzyme members [DP6 (DPL1) and DP10 (DPL2)], are interesting in this regard because of their multiple diverse functions, varying patterns of distribution/localization and subtle, but significant, differences in structure/substrate recognition. In addition, their engagement in cell biological processes involves both enzymatic and nonenzymatic capabilities. This article examines, in detail, our current understanding of the biological involvement of this unique enzyme family and their overall potential as therapeutic targets.
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