期刊
FEBS JOURNAL
卷 277, 期 21, 页码 4370-4375出版社
WILEY
DOI: 10.1111/j.1742-4658.2010.07866.x
关键词
AKAP; cAMP; enzyme complexes; signal transduction
资金
- National Institutes of Health [DK54441]
- Leducq Foundation Transatlantic Network
A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP-dependent protein kinase, phosphoprotein phosphatases, phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview.
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